C. Iser and K. Arca
The authors discuss the pathophysiology of rare primary and secondary headaches in the mechanistic context of the central and peripheral autonomic nervous system.
Autonomic dysfunction is at the forefront of the pathogenesis of multiple primary and secondary headache disorders.
The central autonomic network, the peripheral sympathetic, and the parasympathetic efferents are associated with the generation of headaches and cranial autonomic symptoms (CAS) in migraine and cluster headaches.
Two prominent systems are involved in the development of different headaches, the baroreflex and trigeminovascular systems.
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